The cautionary tale of side effects of chronic Notch1 inhibition.

Not-Approved Weight Gain Supplements as a Cause of AVN: A Cautionary Report

Introduction: Avascular necrosis (AVN) of the femoral head is a leading cause of end-stage joint disease in the young population that can conduct patients to total hip replacement in early life. There are various risk factors including, trauma, corticosteroids, thrombosis, hypertension, and alcohol. There is a growing number of femoral head AVN patients with a history of self-medication with he...

Teachers' Perspectives on the Use of Pedometers as Instructional Technology in Physical Education: A Cautionary Tale

(2008). Teachers' perspectives on the use of pedometers as instructional technology in physical education: A cautionary tale.

Lateral Hypothalamus Corticotropin Releasing Hormone Receptor-1 Inhibition Modulates Stress- Induced Anxiety Behavior

Stress is a reaction to unwanted events disturbing body homeostasis which influences its pathways and target areas. Stress affects the brain through the lateral hypothalamic area (LHA) orexinergic system that mediates the effect of corticotropin-releasing hormone (CRH) through CRH receptor type 1 (CRHr1). Therefore, this study explores the outcome of stress exposure on anxiety development and t...

Targeting Notch1 and proteasome as an effective strategy to suppress T-cell lymphoproliferative neoplasms

The T-cell lymphoproliferative neoplasms (T-LPN) are characterized by a poor clinical outcome. Current therapeutics are mostly non-selective and may induce harmful side effects. It has been reported that NOTCH1 activation mutations frequently associate T-LPN. Because anti-Notch1 based therapies such as γ-secretase inhibitors (GSI) are less efficient and induce considerable side effects, we hypo...

Title: Teacher Effects on Student Achievement and Height: A Cautionary Tale Authors and Affiliations: